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2017-04-17 07:46:29

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<p>Who are the videographers? Lots of theories about GOP operatives, but no one has come forward to take credit, reports our colleague David Weigel. The reason for stopping Etheridge outside a fundraiser for Nancy Pelosi? &quot;A project,&quot; one of the men said on the video. Anything happen that's not on the tape? Unclear, since no other version of the encounter has emerged. </p>
<p>Diuretics are recommended as the first drug of choice in hypertension mainly in the elderly.1,2,3 These drugs reduce cardiovascular morbidity and mortality and all cause mortality in elderly hypertensive patients.3 Much attention has been paid to diuretics induced hypokalaemia,4,5 and a combination of low dose hydrochlorothiazide with potassium sparing diuretic has been recommended to lower the risk of sudden cardiac death.6 Less attention has been paid to other metabolic alterations such as hyponatraemia, hyperglycaemia, hyperuricaemia, hypercalcaemia and hypercholesterolaemia. Clinically significant changes in serum sodium were not reported in a review of 15 studies that evaluated the safety and efficacy of low dose hydrochlorothiazide.7 However, in the Systolic Hypertension in the Elderly Program (SHEP) study,2 4.1% of the elderly hypertensive patients treated with low dose chlorthalidone developed serum sodium levels 130 mmol Hyponatraemia may develop insidiously and can cause significant morbidity such as lethargy, confusion, coma and even death.8,9,10,11 Previous studies reported that hyponatraemia usually developed shortly after diuretic initiation, and even that the use of a single dose of a thiazide diuretic may predict the development of hyponatraemia.12,13 Since diuretics are widely used in hypertension, it is important to identify patients who are at increased risk to develop hyponatraemia. This study was therefore conducted to characterise the clinical findings of the patients who had developed diuretic induced hyponatraemia.
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